CHO-K1/Human BLT1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0123D | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The leukotriene B4 receptor 1 (BLT1) is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4). It is primarily expressed on the surface of immune cells such as neutrophils, monocytes/macrophages, eosinophils, and T cells. Its core function is to serve as a critical mediator of inflammation and immune responses: by sensing LTB4, a potent chemoattractant, it mediates the chemotaxis, adhesion, degranulation, and inflammatory cytokine release of immune cells, thereby driving early inflammatory responses in acute inflammation, host defense, and allergic diseases. Sustained activation of this receptor is closely associated with chronic inflammatory diseases like asthma, atherosclerosis, and rheumatoid arthritis, making it a potential target for anti-inflammatory therapy.
Screeningbio’s CHO-K1/Human BLT1 cell line overexpress LTB4R receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | LTB4R |
Accession Number | NM_181657 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The leukotriene B4 receptor 1 (BLT1) is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4). It is primarily expressed on the surface of immune cells such as neutrophils, monocytes/macrophages, eosinophils, and T cells.
Its core function is to serve as a critical mediator of inflammation and immune responses: by sensing LTB4, a potent chemoattractant, it mediates the chemotaxis, adhesion, degranulation, and inflammatory cytokine release of immune cells, thereby driving early inflammatory responses in acute inflammation, host defense, and allergic diseases.
Sustained activation of this receptor is closely associated with chronic inflammatory diseases like asthma, atherosclerosis, and rheumatoid arthritis, making it a potential target for anti-inflammatory therapy.