Product Description

AMY1 (CTR-RAMP1) is a heterodimeric G protein-coupled receptor complex composed of the calcitonin receptor and receptor activity-modifying protein 1. It is primarily distributed in the central nervous system (e.g., hypothalamus, nucleus accumbens), pancreas, and stomach. Its core function is to act as a high-affinity receptor for amylin and CGRP, mediating potent control over energy homeostasis via signaling pathways such as cAMP inhibition. This includes inducing central satiety, delaying gastric emptying, and modulating glucagon secretion to control postprandial glucose. Thus, AMY1 is a key therapeutic target for type 2 diabetes and obesity, with its agonist (e.g., pramlintide) already in clinical use.

Screeningbio’s CHO-K1/Human CTR-RAMP1 (AMY1) cell line overexpress both CT receptor and RAMP1 accessory protein (also named AMY1). The cell line is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.