CHO-K1/Gα15/Human C5a1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0078D | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The C5a1 receptor (complement C5a receptor 1) is a G protein-coupled receptor primarily expressed on myeloid immune cells such as neutrophils and monocytes/macrophages, belonging to the complement peptide receptor family. Its core function involves activation by the complement activation product C5a to mediate immune cell chemotaxis, degranulation, respiratory burst, and inflammatory cytokine release via G protein signaling pathways, thereby playing a critical role in acute inflammatory responses and host defense. Overactivation of this receptor is closely associated with inflammatory diseases including sepsis, ischemia-reperfusion injury, and rheumatoid arthritis.
Screeningbio’s CHO-K1/Gα15/Human C5a1 cell line overexpress C5a1 receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | C5AR1 |
Accession Number | NM_001736 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The C5a1 receptor (complement C5a receptor 1) is a G protein-coupled receptor primarily expressed on myeloid immune cells such as neutrophils and monocytes/macrophages, belonging to the complement peptide receptor family.
Its core function involves activation by the complement activation product C5a to mediate immune cell chemotaxis, degranulation, respiratory burst, and inflammatory cytokine release via G protein signaling pathways, thereby playing a critical role in acute inflammatory responses and host defense.
Overactivation of this receptor is closely associated with inflammatory diseases including sepsis, ischemia-reperfusion injury, and rheumatoid arthritis.