HEK293T/Mouse GHRH β-Arrestin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-A-0102B | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The growth hormone-releasing hormone receptor (GHRHR) is a G protein-coupled receptor primarily found on somatotrophs in the pituitary gland. Its key function is to bind GHRH, activating the cAMP pathway to stimulate growth hormone (GH) synthesis and pulsatile secretion, thereby regulating body growth and metabolism. Dysregulation of GHRHR is directly linked to endocrine disorders such as acromegaly (overactivity) and growth hormone deficiency (underactivity), making it a critical therapeutic target.
ScreeningBio’s HEK293T/Mouse GHRH β-Arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | GHRHR |
Accession Number | NM_001003685 (Mm) |
Parental Line | HEK293T |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The growth hormone-releasing hormone receptor (GHRHR) is a G protein-coupled receptor primarily found on somatotrophs in the pituitary gland. Its key function is to bind GHRH, activating the cAMP pathway to stimulate growth hormone (GH) synthesis and pulsatile secretion, thereby regulating body growth and metabolism.
Dysregulation of GHRHR is directly linked to endocrine disorders such as acromegaly (overactivity) and growth hormone deficiency (underactivity), making it a critical therapeutic target.