Product Description

Formylpeptide receptor 3 (FPR3) is a member of the formyl peptide receptor family, primarily expressed on monocytes/macrophages and dendritic cells. Unlike its counterparts, it primarily responds to endogenous ligands (e.g., antimicrobial peptide LL-37 and Annexin A1). Its core function is to regulate inflammation resolution, exerting potent anti-inflammatory effects by activating specific signaling pathways to suppress excessive immune responses and promote tissue repair. Its dysfunction is closely linked to chronic inflammation and autoimmune diseases.

ScreeningBio’s HEK293T/Human FPR3 β-Arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.