Product Description

The delta opioid receptor (δ-OR) is one of the three main members of the opioid receptor family, belonging to the G protein-coupled receptor class. It is widely distributed in the central nervous system, particularly in the limbic system (e.g., amygdala, nucleus accumbens), cerebral cortex, and dorsal root ganglia. Its primary function is to bind endogenous opioid peptides (e.g., enkephalins), mediating analgesia (especially against inflammatory and neuropathic pain), regulating mood (such as antidepressant and anxiolytic effects), reward behaviors, and gastrointestinal motility. As it has a far lower tendency to cause respiratory depression and addiction compared to the classical mu opioid receptor, it is considered a highly promising target for developing non-addictive analgesics and antidepressant drugs.

ScreeningBio’s HEK293T/Human δ β-Arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.