HEK293/Human MRGPRX2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0270D | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
MRGPRX2 is a G protein-coupled receptor primarily expressed on the surface of mast cells in skin and mucosal tissues, and is also detectable in some sensory neurons. Its core function is to act as a "multimodal danger signal sensor". It can be activated by various cationic compounds, host defense peptides, and a range of drugs including morphine and muscle relaxants. This activation bypasses the classical IgE pathway to directly trigger mast cell degranulation, mediating non-IgE-dependent itch, neurogenic inflammation, and drug-induced pseudo-allergic reactions. It plays a pivotal role in host defense, chronic itch disorders, and adverse drug reactions.
Screeningbio’s HEK293/Human MRGPRX2 cell line inducible express MRGPRX2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | MRGPRX2 |
Accession Number | SNB-G-0270D |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
MRGPRX2 is a G protein-coupled receptor primarily expressed on the surface of mast cells in skin and mucosal tissues, and is also detectable in some sensory neurons.
Its core function is to act as a "multimodal danger signal sensor". It can be activated by various cationic compounds, host defense peptides, and a range of drugs including morphine and muscle relaxants.
This activation bypasses the classical IgE pathway to directly trigger mast cell degranulation, mediating non-IgE-dependent itch, neurogenic inflammation, and drug-induced pseudo-allergic reactions. It plays a pivotal role in host defense, chronic itch disorders, and adverse drug reactions.