Product Description

ETA (EDNRA), the endothelin type-A receptor, is a G protein-coupled receptor crucial for vasoconstriction and cellular growth. Primarily located in vascular smooth muscle, heart, lungs, and kidneys, it exerts its core physiological functions by specifically binding endothelin-1 (ET-1): mediating potent and sustained vasoconstriction to regulate blood pressure and local blood flow, while also promoting cell proliferation and tissue remodeling. While these functions maintain circulatory homeostasis under normal conditions, its overactivation drives the development of various diseases such as hypertension, pulmonary arterial hypertension, heart failure, and organ fibrosis. Consequently, it has become a key therapeutic target for drugs like bosentan.

Screeningbio’s HEK293/Human ETA cell line overexpress EDNRA and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.