Product Description

The bradykinin B2 receptor is a widely and constitutively expressed G protein-coupled receptor that serves as the primary mediator for the kinin system. It is ubiquitously present on vascular endothelial cells, smooth muscle cells, and neurons. Its key functions include mediating acute vasodilation (leading to hypotension), increasing vascular permeability (causing edema), and eliciting pain and cough reflexes. It also plays a critical role in the pathophysiology of shock.

Screeningbio’s HEK293/Human B2 Gi Gq cell line overexpress BDKRB2 and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.