CHO-K1/Rat S1P1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0135C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Sphingosine 1-phosphate receptor 1 (S1P1) is a G protein-coupled receptor that specifically binds sphingosine 1-phosphate. It is primarily expressed on vascular endothelial cells, lymphocytes, and in the central nervous system. Its core function, mediated via Gi protein signaling, is to orchestrate the recirculation of lymphocytes from lymphoid organs into the bloodstream and to maintain vascular endothelial barrier integrity, serving as a critical gating molecule for immune cell trafficking. This receptor is the target of the multiple sclerosis drug fingolimod, which acts as a functional antagonist to inhibit lymphocyte egress, thereby exerting immunomodulatory effects.
Screeningbio’s CHO-K1/Rat S1P1 cell line overexpress rat S1PR1 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | S1PR1 |
Accession Number | SNB-G-0135C |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Sphingosine 1-phosphate receptor 1 (S1P1) is a G protein-coupled receptor that specifically binds sphingosine 1-phosphate. It is primarily expressed on vascular endothelial cells, lymphocytes, and in the central nervous system.
Its core function, mediated via Gi protein signaling, is to orchestrate the recirculation of lymphocytes from lymphoid organs into the bloodstream and to maintain vascular endothelial barrier integrity, serving as a critical gating molecule for immune cell trafficking.
This receptor is the target of the multiple sclerosis drug fingolimod, which acts as a functional antagonist to inhibit lymphocyte egress, thereby exerting immunomodulatory effects.