CHO-K1/Rat M1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0013C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
M1 (Cholinergic receptor muscarinic 1, CHRM1) is a member of the G protein-coupled receptor family, primarily distributed in the central nervous system, retina, and urinary system. By binding to acetylcholine, M1 activates G proteins and downstream signaling pathways, thus mediating diverse cellular responses. The biological significance of M1 is very broad—it is involved in regulating vagus nerve-induced bronchoconstriction, acid secretion in the gastrointestinal tract, and cognitive functions, among others. Furthermore, its dysfunction is associated with a variety of diseases.
Screeningbio’s CHO-K1/Rat M1 cell line overexpress CHRM1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | CHRM1 |
Accession Number | NM_080773 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
M1 (Cholinergic receptor muscarinic 1, CHRM1) is a member of the G protein-coupled receptor family, primarily distributed in the central nervous system, retina, and urinary system. By binding to acetylcholine, M1 activates G proteins and downstream signaling pathways, thus mediating diverse cellular responses.
The biological significance of M1 is very broad—it is involved in regulating vagus nerve-induced bronchoconstriction, acid secretion in the gastrointestinal tract, and cognitive functions, among others. Furthermore, its dysfunction is associated with a variety of diseases.