CHO-K1/Mouse TSH Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0110B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The thyroid-stimulating hormone receptor (TSHR) is a G protein-coupled receptor that specifically binds thyroid-stimulating hormone. It is primarily located on thyroid follicular epithelial cells and is also expressed in various peripheral tissues such as adipocytes, fibroblasts, and bone cells. Its core function is to mediate TSH signaling by activating the cAMP/PKC pathways, potently regulating the proliferation and differentiation of thyroid cells, as well as the synthesis and secretion of thyroid hormones. It serves as a central hub for maintaining metabolism, growth, and energy balance. Autoantibodies targeting this receptor can cause abnormal activation, leading to autoimmune thyroid diseases like Graves' disease, making TSHR a critical target for thyroid function diagnosis and therapy.
Screeningbio’s CHO-K1/Mouse TSH cell line overexpress mouse TSHR and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | TSHR |
Accession Number | NM_011648 (Mm) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The thyroid-stimulating hormone receptor (TSHR) is a G protein-coupled receptor that specifically binds thyroid-stimulating hormone.
It is primarily located on thyroid follicular epithelial cells and is also expressed in various peripheral tissues such as adipocytes, fibroblasts, and bone cells. Its core function is to mediate TSH signaling by activating the cAMP/PKC pathways, potently regulating the proliferation and differentiation of thyroid cells, as well as the synthesis and secretion of thyroid hormones. It serves as a central hub for maintaining metabolism, growth, and energy balance.
Autoantibodies targeting this receptor can cause abnormal activation, leading to autoimmune thyroid diseases like Graves' disease, making TSHR a critical target for thyroid function diagnosis and therapy.