CHO-K1/Mouse Secretin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0104B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The secretin receptor is a class B G protein-coupled receptor primarily located in the stomach, pancreatic ductal epithelial cells, kidneys, and central nervous system. Its key function is to respond to the intestinal hormone secretin by activating the Gs protein-cAMP signaling pathway, potently stimulating the pancreas to secrete bicarbonate-rich fluid to neutralize duodenal acidity, while also inhibiting gastric acid secretion and modulating renal water-electrolyte balance. This receptor plays a critical role in regulating digestive tract pH and secretory functions, and its dysfunction is associated with diseases such as chronic pancreatitis, peptic ulcers, and gastrinoma.
Screeningbio’s CHO-K1/Mouse Secretin cell line overexpress SCTR and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | SCTR |
Accession Number | NM_001012322 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The secretin receptor is a class B G protein-coupled receptor primarily located in the stomach, pancreatic ductal epithelial cells, kidneys, and central nervous system.
Its key function is to respond to the intestinal hormone secretin by activating the Gs protein-cAMP signaling pathway, potently stimulating the pancreas to secrete bicarbonate-rich fluid to neutralize duodenal acidity, while also inhibiting gastric acid secretion and modulating renal water-electrolyte balance.
This receptor plays a critical role in regulating digestive tract pH and secretory functions, and its dysfunction is associated with diseases such as chronic pancreatitis, peptic ulcers, and gastrinoma.