CHO-K1/Mouse MT2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0148B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
MT2 (Melatonin Receptor 1B, MTNR1B) is one of the two primary high-affinity G protein-coupled receptors for melatonin, co-mediating melatonin signaling with MT1. It is mainly distributed in the retina, suprachiasmatic nucleus of the brain, and peripheral tissues such as pancreatic islet β-cells. Its core functions include participating in dark-adaptation signal transmission in the retina and acting as a “circadian fine-tuner” in the central nervous system, regulating sleep onset and body temperature decline via Gi/o protein pathways. Peripherally, it directly inhibits insulin secretion from pancreatic β-cells, contributing to glucose homeostasis. Genetic polymorphisms of this receptor are significantly associated with the risk of type 2 diabetes, highlighting its role as a key molecule linking the circadian clock to metabolic regulation.
Screeningbio’s CHO-K1/Mouse MT2 cell line overexpress mouse MTNR1B and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | MTNR1B |
Accession Number | SNB-G-0148B |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
MT2 (Melatonin Receptor 1B, MTNR1B) is one of the two primary high-affinity G protein-coupled receptors for melatonin, co-mediating melatonin signaling with MT1.
It is mainly distributed in the retina, suprachiasmatic nucleus of the brain, and peripheral tissues such as pancreatic islet β-cells. Its core functions include participating in dark-adaptation signal transmission in the retina and acting as a “circadian fine-tuner” in the central nervous system, regulating sleep onset and body temperature decline via Gi/o protein pathways. Peripherally, it directly inhibits insulin secretion from pancreatic β-cells, contributing to glucose homeostasis.
Genetic polymorphisms of this receptor are significantly associated with the risk of type 2 diabetes, highlighting its role as a key molecule linking the circadian clock to metabolic regulation.