CHO-K1/Mouse H1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0115B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The histamine H1 receptor (HRH1) is a key G protein-coupled receptor mediating type I allergic reactions. It is widely distributed in vascular endothelial cells, bronchial smooth muscle, skin, and the central nervous system (e.g., hypothalamus and cortex). Its core function, upon binding histamine, is to activate the Gq/11 protein-phospholipase C signaling pathway, triggering rapid-onset allergic symptoms such as vasodilation, increased vascular permeability, and bronchoconstriction. It also participates in regulating central physiological processes like the sleep-wake cycle, appetite, and body temperature. Consequently, the H1 receptor is the primary target of antihistamine drugs (e.g., diphenhydramine, loratadine) used to treat allergic diseases, with its central inhibitory effects also responsible for the sedative side effects of first-generation medications.
Screeningbio’s CHO-K1/Mouse H1 cell line overexpress HRH1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | HRH1 |
Accession Number | NM_008285 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The histamine H1 receptor (HRH1) is a key G protein-coupled receptor mediating type I allergic reactions. It is widely distributed in vascular endothelial cells, bronchial smooth muscle, skin, and the central nervous system (e.g., hypothalamus and cortex).
Its core function, upon binding histamine, is to activate the Gq/11 protein-phospholipase C signaling pathway, triggering rapid-onset allergic symptoms such as vasodilation, increased vascular permeability, and bronchoconstriction. It also participates in regulating central physiological processes like the sleep-wake cycle, appetite, and body temperature.
Consequently, the H1 receptor is the primary target of antihistamine drugs (e.g., diphenhydramine, loratadine) used to treat allergic diseases, with its central inhibitory effects also responsible for the sedative side effects of first-generation medications.