Product Description

Formylpeptide receptor 1 (FPR1) is a G protein-coupled pattern recognition receptor, primarily highly expressed on myeloid immune cells such as neutrophils and monocytes/macrophages, and is also found in epithelial and neuronal cells. Its core function is to recognize formylated peptides released by bacteria or mitochondria, serving as a crucial “alarm sensor” for the body to detect infection and tissue damage. Upon activation, FPR1 drives the chemotaxis of immune cells to sites of infection or inflammation and triggers potent antimicrobial inflammatory responses, including respiratory burst and degranulation, playing a vital role in host defense. Concurrently, its dysregulation is closely associated with chronic inflammation, autoimmune diseases, and cancer progression.

Screeningbio’s CHO-K1/Mouse FPR1 cell line overexpress FPR1 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.