Product Description

ETB (EDNRB), the endothelin type-B receptor, is a G protein-coupled receptor belonging to the same family as ETA. It is widely distributed in vascular endothelial cells, the kidneys (e.g., renal tubules and collecting ducts), the central nervous system, the intestines, and some smooth muscle tissues. Its core function involves dual regulatory roles: on vascular endothelium, ETB receptor activation promotes the release of nitric oxide and prostacyclin, leading to vasodilation, and it helps clear circulating endothelin-1 to regulate its levels; in the kidneys, it participates in regulating water-salt balance and blood pressure; concurrently, it also mediates cell proliferation, migration, and nervous system development and function.

Screeningbio’s CHO-K1/Mouse ETB cell line overexpress EDNRB and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.