CHO-K1/Mouse D1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0082B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Dopamine receptor D1 (D1) is a primary Gs protein-coupled receptor in the dopamine receptor family, mediating the excitatory effects of dopamine. It is highly concentrated in the striatum, nucleus accumbens, and cerebral cortex of the brain, and is also found in the kidneys and vascular smooth muscle. Its key functions include enhancing neuronal excitability, regulating motor control, reinforcing reward and motivational behaviors, promoting memory and cognitive functions, and modulating renal sodium excretion and vasodilation. Consequently, the D1 receptor is a significant therapeutic target for treating Parkinson's disease, cognitive impairment, negative symptoms of schizophrenia, and for blood pressure regulation.
Screeningbio’s CHO-K1/Mouse D1 cell line overexpress DRD1 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | DRD1 |
Accession Number | NM_010076 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Dopamine receptor D1 (D1) is a primary Gs protein-coupled receptor in the dopamine receptor family, mediating the excitatory effects of dopamine. It is highly concentrated in the striatum, nucleus accumbens, and cerebral cortex of the brain, and is also found in the kidneys and vascular smooth muscle.
Its key functions include enhancing neuronal excitability, regulating motor control, reinforcing reward and motivational behaviors, promoting memory and cognitive functions, and modulating renal sodium excretion and vasodilation.
Consequently, the D1 receptor is a significant therapeutic target for treating Parkinson's disease, cognitive impairment, negative symptoms of schizophrenia, and for blood pressure regulation.