CHO-K1/Mouse BB2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0036B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The gastrin-releasing peptide receptor (GRPR), currently designated as BB2, is a G protein-coupled receptor encoded by the GRPR gene in humans, with gastrin-releasing peptide as its endogenous ligand. This receptor is highly expressed in the pancreas and is also present in the stomach, adrenal cortex, and brain. It functions through G protein-mediated activation of the phosphatidylinositol-calcium second messenger system, leading to Akt phosphorylation. The receptor contributes to the regulation of food intake and plays a specific role in the perception and transmission of pruritic stimuli—facilitating itch signal transduction in the spinal cord and promoting scratching behavior, without involvement in pain perception.
Screeningbio’s CHO-K1/Mouse BB2 cell line overexpress BB2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | BB2 |
Accession Number | NM_008177 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The gastrin-releasing peptide receptor (GRPR), currently designated as BB2, is a G protein-coupled receptor encoded by the GRPR gene in humans, with gastrin-releasing peptide as its endogenous ligand. This receptor is highly expressed in the pancreas and is also present in the stomach, adrenal cortex, and brain. It functions through G protein-mediated activation of the phosphatidylinositol-calcium second messenger system, leading to Akt phosphorylation.
The receptor contributes to the regulation of food intake and plays a specific role in the perception and transmission of pruritic stimuli—facilitating itch signal transduction in the spinal cord and promoting scratching behavior, without involvement in pain perception.