CHO-K1/Mouse BB1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0035B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Neuromedin B receptor (BB1) is a seven-transmembrane G protein-coupled receptor that binds to its endogenous ligand, neuromedin B. This neuropeptide functions as a growth factor and mitogen in gastrointestinal epithelial tissues as well as in normal and neoplastic lung tissues. The receptor is involved in regulating various physiological processes including smooth muscle contraction, neuronal responses, and cellular growth. Research indicates that antagonists of this receptor hold potential therapeutic value in inhibiting tumor cell growth, while genetic polymorphisms of the receptor may be associated with susceptibility to schizophrenia.
Screeningbio’s CHO-K1/Mouse BB1 cell line overexpress BB1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | BB1 |
Accession Number | NM_008703 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Neuromedin B receptor (BB1) is a seven-transmembrane G protein-coupled receptor that binds to its endogenous ligand, neuromedin B. This neuropeptide functions as a growth factor and mitogen in gastrointestinal epithelial tissues as well as in normal and neoplastic lung tissues.
The receptor is involved in regulating various physiological processes including smooth muscle contraction, neuronal responses, and cellular growth. Research indicates that antagonists of this receptor hold potential therapeutic value in inhibiting tumor cell growth, while genetic polymorphisms of the receptor may be associated with susceptibility to schizophrenia.