CHO-K1/Human S1P4 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0138A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Sphingosine 1-phosphate receptor 4 (S1P4) is a G protein-coupled receptor of the S1P receptor family that is specifically expressed in the immune system. It is primarily distributed in hematopoietic tissues, lymphoid organs such as the spleen, thymus, and lymph nodes, as well as immune cells including T cells and dendritic cells. Its core function is to regulate lymphocyte migration, homing, and cytokine secretion via Gi/o and G12/13 protein signaling pathways, playing a pivotal role in initiating and modulating adaptive immune responses, and is involved in the pathogenesis of chronic inflammatory and autoimmune diseases.
Screeningbio’s CHO-K1/Human S1P4 cell line overexpress S1PR4 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | S1PR4 |
Accession Number | SNB-G-0138A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Sphingosine 1-phosphate receptor 4 (S1P4) is a G protein-coupled receptor of the S1P receptor family that is specifically expressed in the immune system. It is primarily distributed in hematopoietic tissues, lymphoid organs such as the spleen, thymus, and lymph nodes, as well as immune cells including T cells and dendritic cells.
Its core function is to regulate lymphocyte migration, homing, and cytokine secretion via Gi/o and G12/13 protein signaling pathways, playing a pivotal role in initiating and modulating adaptive immune responses, and is involved in the pathogenesis of chronic inflammatory and autoimmune diseases.