CHO-K1/Human S1P2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0136A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Sphingosine 1-phosphate receptor 2 (S1P2) is one of the five G protein-coupled receptors for sphingosine-1-phosphate. It is widely expressed in the cardiovascular system, central nervous system, liver, kidneys, and various immune cells. Distinct from other family members that primarily promote cell migration, its core function is context-dependent: under physiological conditions, it participates in regulating vascular tone, endothelial barrier function, and cytoskeletal reorganization; under pathological conditions, it potently drives fibrotic responses, inflammatory reactions, and vascular dysfunction via Gα12/13 and Gq signaling pathways, playing crucial roles in diseases such as liver fibrosis, atherosclerosis, hearing loss, and multiple sclerosis.
Screeningbio’s CHO-K1/Human S1P2 cell line overexpress S1PR2 receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | S1PR2 |
Accession Number | SNB-G-0136A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Sphingosine 1-phosphate receptor 2 (S1P2) is one of the five G protein-coupled receptors for sphingosine-1-phosphate. It is widely expressed in the cardiovascular system, central nervous system, liver, kidneys, and various immune cells.
Distinct from other family members that primarily promote cell migration, its core function is context-dependent: under physiological conditions, it participates in regulating vascular tone, endothelial barrier function, and cytoskeletal reorganization; under pathological conditions, it potently drives fibrotic responses, inflammatory reactions, and vascular dysfunction via Gα12/13 and Gq signaling pathways, playing crucial roles in diseases such as liver fibrosis, atherosclerosis, hearing loss, and multiple sclerosis.