

CHO-K1/Human NMU1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0159A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Neuromedin U receptor 1 (NMU1) is a G protein-coupled receptor primarily expressed in the central nervous system (such as the hypothalamus) and the gastrointestinal tract. Its key functions include regulating feeding behavior, energy balance, gastrointestinal motility, and stress responses. Upon activation by its ligand neuromedin U, NMU1 modulates various physiological processes through downstream signaling pathways, playing a significant role in obesity, metabolism, and digestive system function.
Screeningbio’s CHO-K1/Human NMU1 cell line overexpress NMU1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | NMUR1 |
Accession Number | SNB-G-0159A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
![CHO-K1/Human NMU1 Agonist Assay. CHO-K1/Human NMU1 cells were treated with the reference agonist. The assay was run based on Revvity IP-one HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 /IC50 values were determined, using GraphPad Prism software.](https://static.wixstatic.com/media/cbf7de_a302fea9d7af4c7094dae0ec857095cb~mv2.png/v1/fill/w_75,h_75,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/cbf7de_a302fea9d7af4c7094dae0ec857095cb~mv2.png)
Target Background
Neuromedin U receptor 1 (NMU1) is a G protein-coupled receptor primarily expressed in the central nervous system (such as the hypothalamus) and the gastrointestinal tract.
Its key functions include regulating feeding behavior, energy balance, gastrointestinal motility, and stress responses.
Upon activation by its ligand neuromedin U, NMU1 modulates various physiological processes through downstream signaling pathways, playing a significant role in obesity, metabolism, and digestive system function.