CHO-K1/Human MRGPRX1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0269D | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
MRGPRX1 is a G protein-coupled receptor specifically expressed in human sensory neurons, primarily located in distinct neuronal subsets of the dorsal root ganglia and trigeminal ganglia. It recognizes various exogenous (e.g., bee venom melittin) and endogenous ligands. Its core function is to act as a specific sensor for itch perception, mainly mediating non-histaminergic itch signaling. It also participates in regulating neurogenic inflammation and pain sensitization, making it a critical target connecting the immune and sensory nervous systems for developing novel anti-pruritic drugs.
Screeningbio’s CHO-K1/Human MRGPRX1 cell line overexpress MRGPRX1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | MRGPRX1 |
Accession Number | SNB-G-0269D |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
MRGPRX1 is a G protein-coupled receptor specifically expressed in human sensory neurons, primarily located in distinct neuronal subsets of the dorsal root ganglia and trigeminal ganglia.
It recognizes various exogenous (e.g., bee venom melittin) and endogenous ligands. Its core function is to act as a specific sensor for itch perception, mainly mediating non-histaminergic itch signaling.
It also participates in regulating neurogenic inflammation and pain sensitization, making it a critical target connecting the immune and sensory nervous systems for developing novel anti-pruritic drugs.