CHO-K1/Human Motilin(GPR38) Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0157A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The motilin receptor (GPR38) is a G protein-coupled receptor specifically activated by the hormone motilin. It is primarily distributed in the smooth muscle cells of the gastrointestinal tract (especially the duodenum and antrum) and the enteric nervous system. Its core function is to initiate and control the migrating motor complex during the interdigestive period, which clears undigested food residues from the stomach and upper small intestine through periodic contractions to prepare for the next meal. It plays a key role in regulating gastric emptying, promoting intestinal peristalsis, and generating hunger sensations. Its analogs (e.g., erythromycin) are used to treat gastrointestinal motility disorders.
Screeningbio’s CHO-K1/Human Motilin(GPR38) cell line overexpress Motilin receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | MLNR |
Accession Number | SNB-G-0157A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The motilin receptor (GPR38) is a G protein-coupled receptor specifically activated by the hormone motilin. It is primarily distributed in the smooth muscle cells of the gastrointestinal tract (especially the duodenum and antrum) and the enteric nervous system.
Its core function is to initiate and control the migrating motor complex during the interdigestive period, which clears undigested food residues from the stomach and upper small intestine through periodic contractions to prepare for the next meal.
It plays a key role in regulating gastric emptying, promoting intestinal peristalsis, and generating hunger sensations. Its analogs (e.g., erythromycin) are used to treat gastrointestinal motility disorders.