Product Description

Metabotropic glutamate receptor 6 (mGlu6) is a class C G protein-coupled receptor exclusively expressed at the dendritic terminals of ON-bipolar cells in the retina. Its core function is to serve as a critical molecular component of phototransduction: in darkness, photoreceptors continuously release glutamate to activate mGlu6, initiating its coupled Gαo protein signaling pathway and ultimately causing hyperpolarization of ON-bipolar cells; upon light exposure, reduced glutamate release turns off this pathway, leading to cell depolarization and thereby converting light stimuli into neural signals. mGlu6 is essential for the normal function of the ON visual pathway, and mutations in its gene cause congenital stationary night blindness.

Screeningbio’s CHO-K1/Human mGlu6 cell line overexpress mGlu6 receptor and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.