CHO-K1/Human LPA3 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0131A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Lysophosphatidic acid receptor 3 (LPA3) is a G protein-coupled receptor that specifically recognizes lysophosphatidic acid. It is primarily distributed in reproductive tissues such as the uterus, ovaries, and testis, as well as in certain brain regions and the cardiovascular system. Its core function is to regulate cell chemotaxis, proliferation, and differentiation by selectively coupling to Gαq/11 protein. In the female reproductive system, it governs critical processes including embryo implantation, endometrial receptivity, and decidualization, and also participates in pain modulation and cardiovascular responses. This receptor is vital in reproductive physiology and pathology, with its dysfunction linked to infertility, embryonic developmental disorders, and the pathogenesis of certain tumors.
Screeningbio’s CHO-K1/Human LPA3 cell line overexpress LPAR3 receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | LPAR3 |
Accession Number | SNB-G-0131A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Lysophosphatidic acid receptor 3 (LPA3) is a G protein-coupled receptor that specifically recognizes lysophosphatidic acid. It is primarily distributed in reproductive tissues such as the uterus, ovaries, and testis, as well as in certain brain regions and the cardiovascular system.
Its core function is to regulate cell chemotaxis, proliferation, and differentiation by selectively coupling to Gαq/11 protein. In the female reproductive system, it governs critical processes including embryo implantation, endometrial receptivity, and decidualization, and also participates in pain modulation and cardiovascular responses.
This receptor is vital in reproductive physiology and pathology, with its dysfunction linked to infertility, embryonic developmental disorders, and the pathogenesis of certain tumors.