CHO-K1/Human LPA2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0130A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Lysophosphatidic acid receptor 2 (LPA2) is a G protein-coupled receptor that mediates lysophosphatidic acid signaling. It is predominantly distributed in immune organs such as the intestines and spleen, as well as various epithelial and immune cells. Its core function involves regulating cell migration, proliferation, survival, and intercellular adhesion by activating Gαi, Gαq, and Gα12/13 signaling pathways. It plays a pivotal role in epithelial barrier repair, inflammatory responses, and immune regulation. While it contributes to tissue regeneration and wound healing, its abnormal activation is closely linked to the progression and metastasis of certain cancers (e.g., colorectal cancer), making it a potential target for modulating intestinal homeostasis and inflammation-related diseases.
Screeningbio’s CHO-K1/Human LPA2 cell line overexpress LPAR2 receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | LPAR2 |
Accession Number | SNB-G-0130A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Lysophosphatidic acid receptor 2 (LPA2) is a G protein-coupled receptor that mediates lysophosphatidic acid signaling. It is predominantly distributed in immune organs such as the intestines and spleen, as well as various epithelial and immune cells.
Its core function involves regulating cell migration, proliferation, survival, and intercellular adhesion by activating Gαi, Gαq, and Gα12/13 signaling pathways. It plays a pivotal role in epithelial barrier repair, inflammatory responses, and immune regulation.
While it contributes to tissue regeneration and wound healing, its abnormal activation is closely linked to the progression and metastasis of certain cancers (e.g., colorectal cancer), making it a potential target for modulating intestinal homeostasis and inflammation-related diseases.