CHO-K1/Human LPA1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0129A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Lysophosphatidic acid receptor 1 (LPA1) is a G protein-coupled receptor that mediates lysophosphatidic acid (LPA) signaling. It is widely distributed in the central nervous system (e.g., hippocampus, cortex, spinal cord), lungs, kidneys, fibroblasts, and the reproductive system. Its core function is to regulate cell migration, proliferation, survival, and morphological changes by activating multiple downstream pathways (Gαi/o, Gαq/11, Gα12/13). It plays critical roles in physiological and pathological processes such as embryonic development (particularly of the nervous system), neural synaptic plasticity, pulmonary fibrosis, pain perception, and cancer metastasis, making it an important therapeutic target for diseases like idiopathic pulmonary fibrosis.
Screeningbio’s CHO-K1/Human LPA1 cell line overexpress LPAR1 receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | LPAR1 |
Accession Number | SNB-G-0129A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Lysophosphatidic acid receptor 1 (LPA1) is a G protein-coupled receptor that mediates lysophosphatidic acid (LPA) signaling.
It is widely distributed in the central nervous system (e.g., hippocampus, cortex, spinal cord), lungs, kidneys, fibroblasts, and the reproductive system. Its core function is to regulate cell migration, proliferation, survival, and morphological changes by activating multiple downstream pathways (Gαi/o, Gαq/11, Gα12/13).
It plays critical roles in physiological and pathological processes such as embryonic development (particularly of the nervous system), neural synaptic plasticity, pulmonary fibrosis, pain perception, and cancer metastasis, making it an important therapeutic target for diseases like idiopathic pulmonary fibrosis.