CHO-K1/Human HCA3 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0121A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Hydroxycarboxylic acid receptor 3 (HCA3), also known as GPR109B, is a member of the HCA receptor family primarily expressed in primates. It is distributed in immune cells (e.g., monocytes/macrophages), adipose tissue, and the small intestine. Its core function is to mediate anti-inflammatory responses and inhibit lipolysis by sensing endogenous metabolites such as butyrate and β-hydroxybutyrate, playing a role in linking gut microbiota metabolism with immune homeostasis and energy balance. It is considered a potential regulatory node connecting nutrition, immunity, and metabolism.
Screeningbio’s CHO-K1/Human HCA3 cell line overexpress HCAR3 receptor and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | HCAR3 |
Accession Number | NM_006018 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Hydroxycarboxylic acid receptor 3 (HCA3), also known as GPR109B, is a member of the HCA receptor family primarily expressed in primates.
It is distributed in immune cells (e.g., monocytes/macrophages), adipose tissue, and the small intestine. Its core function is to mediate anti-inflammatory responses and inhibit lipolysis by sensing endogenous metabolites such as butyrate and β-hydroxybutyrate, playing a role in linking gut microbiota metabolism with immune homeostasis and energy balance.
It is considered a potential regulatory node connecting nutrition, immunity, and metabolism.