CHO-K1/Human HCA2(GPR109A) Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0120A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Hydroxycarboxylic acid receptor 2 (HCA2), also known as GPR109A, is a G protein-coupled receptor primarily activated by ketone bodies such as β-hydroxybutyrate. It is highly expressed in adipocytes, immune cells (e.g., macrophages, dendritic cells), and skin keratinocytes. Its core function is to serve as a hub connecting energy metabolism and immune regulation: in adipose tissue, it potently inhibits lipolysis via the Gi protein signaling pathway, reducing free fatty acid release; in the immune system, it mediates significant anti-inflammatory and anti-atherosclerotic effects. This receptor is the primary target of the lipid-lowering drug niacin and a key molecule linking ketosis, energy homeostasis, and inflammatory control.
Screeningbio’s CHO-K1/Human HCA2 cell line overexpress HCAR2 receptor and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | HCAR2 |
Accession Number | NM_177551 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Hydroxycarboxylic acid receptor 2 (HCA2), also known as GPR109A, is a G protein-coupled receptor primarily activated by ketone bodies such as β-hydroxybutyrate. It is highly expressed in adipocytes, immune cells (e.g., macrophages, dendritic cells), and skin keratinocytes.
Its core function is to serve as a hub connecting energy metabolism and immune regulation: in adipose tissue, it potently inhibits lipolysis via the Gi protein signaling pathway, reducing free fatty acid release; in the immune system, it mediates significant anti-inflammatory and anti-atherosclerotic effects.
This receptor is the primary target of the lipid-lowering drug niacin and a key molecule linking ketosis, energy homeostasis, and inflammatory control.