CHO-K1/Human H3 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0117A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The histamine H3 receptor (HRH3) is a G protein-coupled receptor that primarily functions as a presynaptic autoreceptor. It is highly concentrated on histaminergic neuron terminals in the central and peripheral nervous systems and is also distributed on other neurons (e.g., cholinergic, dopaminergic). Its core function is to exert potent negative feedback inhibition on the release of histamine and other neurotransmitters (such as acetylcholine, dopamine, and serotonin) via the Gi/o protein signaling pathway, thereby finely regulating various neurophysiological processes including wakefulness, attention, cognition and memory, appetite, and pain perception. This receptor is a potential therapeutic target for neuropsychiatric disorders such as narcolepsy, attention deficit hyperactivity disorder, Alzheimer's disease, and epilepsy.
Screeningbio’s CHO-K1/Human H3 cell line overexpress HRH3 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | HRH3 |
Accession Number | NM_007232 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The histamine H3 receptor (HRH3) is a G protein-coupled receptor that primarily functions as a presynaptic autoreceptor. It is highly concentrated on histaminergic neuron terminals in the central and peripheral nervous systems and is also distributed on other neurons (e.g., cholinergic, dopaminergic).
Its core function is to exert potent negative feedback inhibition on the release of histamine and other neurotransmitters (such as acetylcholine, dopamine, and serotonin) via the Gi/o protein signaling pathway, thereby finely regulating various neurophysiological processes including wakefulness, attention, cognition and memory, appetite, and pain perception.
This receptor is a potential therapeutic target for neuropsychiatric disorders such as narcolepsy, attention deficit hyperactivity disorder, Alzheimer's disease, and epilepsy.