CHO-K1/Human GPR39 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0244A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
GPR39 is a G protein-coupled receptor (GPCR) widely recognized as a key zinc ion (Zn²⁺) sensor . It is broadly expressed in the pancreas, gastrointestinal tract, liver, adipose tissue, and the central nervous system (e.g., cerebral cortex, hippocampus, and amygdala) . Its primary function is to mediate Zn²⁺ signaling, participating in the regulation of various physiological processes such as insulin secretion, gastrointestinal motility, epithelial repair, neuronal function, and anti-inflammatory responses . Dysregulation of GPR39 is associated with diseases including diabetes, depression, obesity, and certain cancers, making it a potential therapeutic target .
Screeningbio’s CHO-K1/Human GPR39 cell line overexpress GPR39 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | GPR39 |
Accession Number | NM_001508 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
GPR39 is a G protein-coupled receptor (GPCR) widely recognized as a key zinc ion (Zn²⁺) sensor . It is broadly expressed in the pancreas, gastrointestinal tract, liver, adipose tissue, and the central nervous system (e.g., cerebral cortex, hippocampus, and amygdala).
Its primary function is to mediate Zn²⁺ signaling, participating in the regulation of various physiological processes such as insulin secretion, gastrointestinal motility, epithelial repair, neuronal function, and anti-inflammatory responses.
Dysregulation of GPR39 is associated with diseases including diabetes, depression, obesity, and certain cancers, making it a potential therapeutic target.