CHO-K1/Human GHSR Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0101D | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor with high affinity for ghrelin. It is primarily distributed in brain regions regulating feeding and growth, such as the hypothalamic arcuate and ventromedial nuclei, and is also found in peripheral tissues including the pituitary, pancreas, myocardium, and gastrointestinal tract. Its core function is to serve as a critical hub for ghrelin signaling, potently stimulating growth hormone secretion to regulate growth, energy balance, and appetite, while extensively participating in glucose/lipid metabolism, cardiovascular function, and stress responses. Dysregulation of GHSR is closely associated with metabolic disorders such as obesity, diabetes, and heart failure.
Screeningbio’s CHO-K1/Human GHSR cell line overexpress GHSR receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | GHSR |
Accession Number | NM_198407 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor with high affinity for ghrelin. It is primarily distributed in brain regions regulating feeding and growth, such as the hypothalamic arcuate and ventromedial nuclei, and is also found in peripheral tissues including the pituitary, pancreas, myocardium, and gastrointestinal tract.
Its core function is to serve as a critical hub for ghrelin signaling, potently stimulating growth hormone secretion to regulate growth, energy balance, and appetite, while extensively participating in glucose/lipid metabolism, cardiovascular function, and stress responses.
Dysregulation of GHSR is closely associated with metabolic disorders such as obesity, diabetes, and heart failure.