CHO-K1/Human GAL1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0098A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Galanin receptor 1 (GALR1) is a G protein-coupled receptor (GPCR) with high affinity for the neuropeptide galanin. It is primarily distributed in the central nervous system, including the hypothalamus, amygdala, and dorsal horn of the spinal cord, as well as in some peripheral tissues. Its core function is to mediate the potent inhibitory signals of galanin by activating Gi/o proteins to suppress neuronal excitability and reduce neurotransmitter release, thereby playing a key role in regulating pain perception, mood and stress responses, feeding behavior, and seizure threshold. Dysregulation of GALR1 signaling is closely associated with neuropathic pain, mood disorders, and epilepsy, making it a potential therapeutic target for related neurological diseases.
Screeningbio’s CHO-K1/Human GAL1 cell line overexpress GALR1 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | GAL1 receptor |
Accession Number | NM_001480 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Galanin receptor 1 (GALR1) is a G protein-coupled receptor (GPCR) with high affinity for the neuropeptide galanin. It is primarily distributed in the central nervous system, including the hypothalamus, amygdala, and dorsal horn of the spinal cord, as well as in some peripheral tissues.
Its core function is to mediate the potent inhibitory signals of galanin by activating Gi/o proteins to suppress neuronal excitability and reduce neurotransmitter release, thereby playing a key role in regulating pain perception, mood and stress responses, feeding behavior, and seizure threshold.
Dysregulation of GALR1 signaling is closely associated with neuropathic pain, mood disorders, and epilepsy, making it a potential therapeutic target for related neurological diseases.