CHO-K1/Human D2S Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0083E | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The dopamine D2 receptor short isoform is a major splice variant of the D2 receptor characterized by a shorter third intracellular loop. It is predominantly localized to the presynaptic terminals of midbrain dopaminergic neurons, where it functions as a critical autoreceptor. At the cellular level, it provides negative feedback to inhibit dopamine synthesis and release via Gi/o signaling pathways, thereby finely tuning the strength and duration of dopaminergic transmission. It is also found on some postsynaptic membranes. Due to its unique functions, D2S is a key molecule in regulating motor function, reward mechanisms, and the pathophysiology of schizophrenia, making it one of the important targets for antipsychotic drugs.
Screeningbio’s CHO-K1/Human D2S cell line overexpress DRD2S and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | DRD2S |
Accession Number | NM_016574 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The dopamine D2 receptor short isoform is a major splice variant of the D2 receptor characterized by a shorter third intracellular loop. It is predominantly localized to the presynaptic terminals of midbrain dopaminergic neurons, where it functions as a critical autoreceptor.
At the cellular level, it provides negative feedback to inhibit dopamine synthesis and release via Gi/o signaling pathways, thereby finely tuning the strength and duration of dopaminergic transmission. It is also found on some postsynaptic membranes.
Due to its unique functions, D2S is a key molecule in regulating motor function, reward mechanisms, and the pathophysiology of schizophrenia, making it one of the important targets for antipsychotic drugs.