CHO-K1/Human CRF2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0081A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The CRF2 receptor (CRHR2), another subtype of the corticotropin-releasing hormone receptor, exhibits high affinity for the ligands urocortin 1, 2, and 3. Its distribution in the brain differs from CRF1, being concentrated in areas like the lateral septum, hypothalamus, and amygdala; peripherally, it is widely expressed in the heart, skeletal muscle, and gastrointestinal tract. Functionally, the CRF2 receptor is believed to buffer or counteract the excessive stress responses mediated by the CRF1 receptor, contributing to reduced anxiety, suppressed appetite, enhanced cardiac function, and regulated gastrointestinal motility. Consequently, CRF2 receptor agonists are under investigation for treating anxiety disorders and heart failure.
Screeningbio’s CHO-K1/Human CRF2 cell line overexpress CRHR2 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | CRHR2 |
Accession Number | NM_001883 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The CRF2 receptor (CRHR2), another subtype of the corticotropin-releasing hormone receptor, exhibits high affinity for the ligands urocortin 1, 2, and 3. Its distribution in the brain differs from CRF1, being concentrated in areas like the lateral septum, hypothalamus, and amygdala; peripherally, it is widely expressed in the heart, skeletal muscle, and gastrointestinal tract.
Functionally, the CRF2 receptor is believed to buffer or counteract the excessive stress responses mediated by the CRF1 receptor, contributing to reduced anxiety, suppressed appetite, enhanced cardiac function, and regulated gastrointestinal motility. Consequently, CRF2 receptor agonists are under investigation for treating anxiety disorders and heart failure.