CHO-K1/Human CB2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0049A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The cannabinoid receptor 2 (CB2) is a G protein-coupled receptor within the endocannabinoid system, primarily distributed in the peripheral immune system (e.g., spleen, tonsils, and immune cells like B cells, T cells, and macrophages), and also expressed in microglia of the central nervous system. Its core function is to modulate immune responses and inflammation; activation suppresses pro-inflammatory cytokine release, exerting anti-inflammatory and immunomodulatory effects. Thus, CB2 is a non-psychoactive potential target for treating inflammatory diseases, neuropathic pain, and autoimmune disorders.
Screeningbio’s CHO-K1/Human CB2 cell line overexpress CNR2 and is designed to detect decreases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | CNR2 |
Accession Number | NM_001841 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The cannabinoid receptor 2 (CB2) is a G protein-coupled receptor within the endocannabinoid system, primarily distributed in the peripheral immune system (e.g., spleen, tonsils, and immune cells like B cells, T cells, and macrophages), and also expressed in microglia of the central nervous system.
Its core function is to modulate immune responses and inflammation; activation suppresses pro-inflammatory cytokine release, exerting anti-inflammatory and immunomodulatory effects. Thus, CB2 is a non-psychoactive potential target for treating inflammatory diseases, neuropathic pain, and autoimmune disorders.