CHO-K1/Human APJ β-Arrestin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-A-0033E | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Apelin receptor (APLNR) is a member of the class A G protein-coupled receptor family. It is widely expressed throughout the body in various organs and tissues, including the brain, heart, liver, kidneys, lungs, stomach, uterus, testes, adipose tissue, skin, limbs, placenta, as well as the central nervous and cardiovascular systems. This receptor and its ligands are involved in numerous physiological functions and pathophysiological processes, making it a critical potential therapeutic target for diseases such as ischemic heart disease, hypertension, and heart failure.
ScreeningBio’s human APJ β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | APLNR |
Accession Number | NM 005161(Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Apelin receptor (APLNR) is a member of the class A G protein-coupled receptor family. It is widely expressed throughout the body in various organs and tissues, including the brain, heart, liver, kidneys, lungs, stomach, uterus, testes, adipose tissue, skin, limbs, placenta, as well as the central nervous and cardiovascular systems.
This receptor and its ligands are involved in numerous physiological functions and pathophysiological processes, making it a critical potential therapeutic target for diseases such as ischemic heart disease, hypertension, and heart failure.