Product Description

AMY2 (CTR-RAMP2) is a subtype of the amylin receptor, a heterodimeric G protein-coupled receptor complex composed of the calcitonin receptor and receptor activity-modifying protein 2. It serves as a receptor not only for amylin but also for adrenomedullin. Compared to AMY1 and AMY3, its functional studies are still evolving, but it is known to be involved in regulating energy metabolism. Research indicates that the subunits of AMY2 tend to dissociate in the resting state, and binding of ligands like amylin promotes subunit association and activates downstream signaling pathways. Therefore, AMY2, along with AMY1 and AMY3, is considered part of the potential drug target network for treating type 2 diabetes and obesity.

Screeningbio’s CHO-K1/Human CTR-RAMP2 (AMY2) cell line overexpress both CT receptor and RAMP2 accessory protein (also named AMY2). The cell line is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.