CHO-K1/Mouse δ Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0173B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The delta opioid receptor (δ-OR) is one of the three main members of the opioid receptor family, belonging to the G protein-coupled receptor class. It is widely distributed in the central nervous system, particularly in the limbic system (e.g., amygdala, nucleus accumbens), cerebral cortex, and dorsal root ganglia. Its primary function is to bind endogenous opioid peptides (e.g., enkephalins), mediating analgesia (especially against inflammatory and neuropathic pain), regulating mood (such as antidepressant and anxiolytic effects), reward behaviors, and gastrointestinal motility. As it has a far lower tendency to cause respiratory depression and addiction compared to the classical mu opioid receptor, it is considered a highly promising target for developing non-addictive analgesics and antidepressant drugs.
Screeningbio’s CHO-K1/Mouse δ cell line overexpress OPRD1 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | OPRD1 |
Accession Number | NM_013622 (Mm) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The delta opioid receptor (δ-OR) is one of the three main members of the opioid receptor family, belonging to the G protein-coupled receptor class.
It is widely distributed in the central nervous system, particularly in the limbic system (e.g., amygdala, nucleus accumbens), cerebral cortex, and dorsal root ganglia. Its primary function is to bind endogenous opioid peptides (e.g., enkephalins), mediating analgesia (especially against inflammatory and neuropathic pain), regulating mood (such as antidepressant and anxiolytic effects), reward behaviors, and gastrointestinal motility.
As it has a far lower tendency to cause respiratory depression and addiction compared to the classical mu opioid receptor, it is considered a highly promising target for developing non-addictive analgesics and antidepressant drugs.