CHO-K1/Mouse GPBA Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0034B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The G protein-coupled bile acid receptor 1 (GPBA/TGR5) is a receptor activated by bile acids. It is primarily expressed in the distal ileum, gallbladder, brown adipose tissue, and immune cells (e.g., macrophages). Its core function is to act as a bile acid "sensor." Upon activation, it regulates energy metabolism, glucose homeostasis, and inflammatory responses via cAMP signaling, promoting energy expenditure, improving insulin sensitivity, inhibiting macrophage inflammation, and modulating gallbladder filling. Thus, GPBA is a key potential therapeutic target for type 2 diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis.
Screeningbio’s H CHO-K1/Mouse GPBA cell line inducibly express GPBAR1 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | GPBAR1 |
Accession Number | NM_174985 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The G protein-coupled bile acid receptor 1 (GPBA/TGR5) is a receptor activated by bile acids. It is primarily expressed in the distal ileum, gallbladder, brown adipose tissue, and immune cells (e.g., macrophages).
Its core function is to act as a bile acid "sensor." Upon activation, it regulates energy metabolism, glucose homeostasis, and inflammatory responses via cAMP signaling, promoting energy expenditure, improving insulin sensitivity, inhibiting macrophage inflammation, and modulating gallbladder filling.
Thus, GPBA is a key potential therapeutic target for type 2 diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis.