信号通路 (Signaling Pathway)

 

Cell signaling is a process of the cells to perceive and correctly respond to their microenvironment and this ability is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing may cause diseases such as cancer, autoimmunity, and diabetes.

 

During drug discovery processes, monitoring the outcomes of targeting cell signaling becomes essential since the readouts can be applied for target identification and validation, as well as lead identification and assessment. Furthermore, the optimization of drug candidates and deep dissection of mechanisms of action require cellular measurements of the signaling pathway activities.

 

ScreeNingBio offers a comprehensive collection of cell-based pathway indicator assays designed to detect activation or inhibition of complex signal transduction pathways in response to a small molecule or biologic.

 

Reporter Gene Assays: Luminescence-based assays to monitor the activation or inhibition in signal pathways.